Paediatric Medicines

2.5.5 Drugs affecting renin-angiotensin system


  • Tablets 2.5mg, 5mg, 10mg, 20mg

2.10 Fibrinolytic-drugs

Alteplase Actilyse Cathflo

  • 1 vial with powder contains:2 mg alteplase (corresponding to 1,160,000 IU)
  • Paediatric central venous catheter management

4.1.1 Hypnotics


  • Melatonin m/r 2mg tablets are approved for use only to aid sleep cycle synchronisation in children with sensory impairment, autistic spectrum disorder, in other neurodisability / neuropsychiatric / neurodevelopmental disorders including ADHD when behavioural measures have been insufficient and also to induce sleep in children undergoing sleep EEG.
  • Melatonin m/r 2mg tablets are licensed for use in adults over 55, use in children is an ‘off label' use. The MHRA state that, where available a licensed preparation should be used where possible (ie. 2mg tablets which are licensed)

4.4 Central nervous system stimulants

Methylphenidate CD

Lisdexamfetamine CD 

Dexamfetamine Sulphate CD


4.8.1 Control of epilepsy


  • Tablets 250mg, 500mg, 750mg, 1g (Category 3 MHRA)
  • Oral solutionSF 100mg/ml
  • Granules in sachets, 250mg, 500mg and 1000mg Desitrend (second line use only)
  • Concentrate for I/V infusion 100mg/ml 5ml vial

    4.8.2 Status epilepticus

    Midazolam Maleate Oromucosal (Epistatus) CD

    Other Useful Information

    Sodium valproate

    • Crushable tablet 100mg
    • E/C tablets 200mg, 500mg
    • m/r tablet 200mg, 300mg, 500mg (Category 2 MHRA)
    • m/r capsules 150mg, 300mg
    • LiquidSF 200mg/5ml
    • Intravenous injection 400mg

    MHRA Drug Safety Update 24th April 2018 

    Antibiotics Guidance for Primary Care

    5.1.7 Some other antibacterials

    Colistimethate sodium (Promixin)

    • Powder for nebuliser solution 1million-unit
    • For use in paediatrics only following initiation by specialist.

    5.7 Lyme Disease

    • For up to date information relating diagnosing and managing Lyme Disease including treatment doses for children see NICE Guideline NG95  April 2018 

    Doxycycline, Amoxycillin, Azithromycin

          6.1.6 Blood Glucose Monitoring

          Freestyle Libre

          • Approved for use according to BSW STP Policy March 2018
          • Initiation, patient contract, prescribing and 6 month review to be managed by Specialist Teams 
          • Freestyle Libre BSW STP Policy March 2018

          6.5.1  Growth Hormone


          6.2.2  Bisphosphonates

          Zoledronic Acid

          • IV Infusion 800 micrograms/ml 5ml (4mg) vial
          • Osteogenesis imperfecta and other low bone mass conditions as per the Bristol Childrens Hospital Guideline. Six monthly infusion.

          Drooling Guidelines

          Hyoscine hydrobromide

          • Scopoderm® 1.5mg patch 
          • Not licensed for this indication.
          • Only licensed from age 10 for travel sickness. Change patch every 72 hrs

          Trihexyphenidyl tablets 

          • 2mg tablets, 5mg tablets, Oral solution 5mg/5ml x 200ml 
          • Not licensed for this indication.“Not recommended” for children in the SPC. But is listed in the BNF for children.
          • 1mg bd titrated up to 2mg tds 

          Glycopyrronium Sialanar

          • 320 micrograms /ml oral solution
          • Sialanar® is licensed for symptomatic treatment of severe sialorrhoea (chronic pathological drooling) in children and adolescents aged 3 years and older with chronic neurological disorders (short term intermittent use)


          Oralvac Compact 

          • Oral mucosal solution (unlicensed named patient) Consultant Specialist only
          • Liquid dispenser bottles (initial pack for updosing then a maintenance pack)
          • One to three sublingual doses (pumps approx 0.07ml) per day for 8-12 months per year for 3 years.
          • For treatment of severe allergic rhinitis and  severe allergic conjuntivitis not responding to standard treatment

          Last updated by: Joy Craine on 16-07-2018 20:39